Anemia is a condition in which the body has fewer red blood cells than normal. Red blood cells work to carry oxygen to tissues and organs throughout the body. With anemia, red blood cells carry less oxygen to tissues and organs, meaning theses tissues and organs may not function as well as they do in a healthy individual.
Anemia commonly occurs in people with chronic kidney disease or CKD. Anemia might begin to develop in the early stages of CKD, when someone has 20 to 50 percent of normal kidney function. Anemia tends to worsen as CKD progresses.
The purpose of this multi-center study in non-dialysis subjects with anemia associated with CKD is to evaluate safety, efficacy and quality of life of daprodustat compared to placebo.