According to the National Psoriasis Foundation, Palmoplantar Pustulosis is a disease that causes pustules, or blisters to form on the palms of the hand and soles of the feet. It commonly affects the base of the thumb and the sides of the heels. Pustules initially appear in a studded pattern on top of red plaques of skin, but then turn brown, peel and become crusted. Palmoplantar Pustulosis is usually cyclical, with new crops of pustules followed by periods of low activity. There is no cure for Palmoplantar Pustulosis but treatment can help with symptoms.
The primary objective of this study is to assess the efficacy of RIST4721 versus placebo in adult subjects with moderate to severe palmoplantar pustulosis using a range of efficacy endpoints. The secondary objective of the trial is to assess the safety of RIST4721 versus placebo in adult subjects with moderate to severe palmoplantar pustulosis.
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